Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 145-Triphosphate Receptor Type I IP3R; InsP3R type I; insP3R1; InsP>3<R type I; IP-3-R; IP3 receptor; IP3 receptor isoform 1; IP3R 1; opisthotonus; Protein PCD-6; protein phosphatase 1, regulatory subunit 94; Purkinje cell protein 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Cat # 11528861
100 µL
Cat # 16352695
100 µL
Cat # 16306124
100 µL
Cat # 11523851
100 µL
Cat # 16332685
100 µL
Cat # 17156173
100 µL
Cat # 16549691
100 µL
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